The Divisions of Chemical, Bioengineering and Environmental Transport (CBET) and Civil, Mechanical, and Manufacturing Infrastructure (CMMI) in the Engineering Directorate of the National Science Foundation (NSF) are partnering with the Center for the Advancement of Science in Space, Inc. (CASIS) to solicit research projects in the fields of tissue engineering and mechanobiology that can utilize the International Space Station (ISS) National Lab to conduct research that will benefit life on Earth. Topics must fit the scope of either the Biomechanics and Mechanobiology Program or the Engineering of Biomedical Systems Program and must address fundamental engineering gaps. For utilization of the ISS National Lab through this solicitation, individuals and entities must qualify as a United States citizen or alien admitted for permanent residence in the United States, or as a corporation, partnership, or other organization organized under the laws of the United States, respectively.