Tandem mass spectrometry is invaluable for chemical structure elucidation via examination of fragment ions after the activation and dissociation of gaseous precursor ions. However, neutral fragments are ignored and not detected by MS.
Our lab has been working on atmospheric pressure thermal dissociation method (APTD)24-27 which dissociates ions outside mass spectrometer and thus allows re-ionization of neutral fragments.
This approach helps to gain increased structure information about both proteins and organic molecules such as synthetic drugs. It could find applications in both forensic chemistry and proteomics.
References
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22. J. Wang, C. Wei, X. Li, P. Zhao, C. Shan, L. Wojtas, H. Chen, X. Shi*, Chem. Eur. J. 2020, 26, Accepted.
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Hao Chen
hao.chen.2@njit.edu