Small Grants to Enhance the Use of the All of Us Research Program’s Data (R03 Clinical Trial Not Allowed)
Funding Agency:
- National Institutes of Health
Companion Funding Opportunity: RFA-PM-23-001 , R21 Exploratory/Developmental Grants
The All of Us Research Program is building a database to help transform the future of health research by equipping researchers nationwide with expansive health data from various populations, including those populations understudied in biomedical research. The All of Us Research Program characterizes populations that are underrepresented in biomedical research (UBR) as groups that historically have low participation rates in biomedical research studies (including clinical trials). These groups include (1) racial and ethnic minority groups and/or (2) sexual and gender minority groups; (3) children and older adults; and people with (4) disabilities, (5) barriers to accessing health care, (6) lower incomes, or (7) limited educational attainment; and/or (8) residents of rural areas. Data are refreshed once or twice a year. Data available to registered researchers include:
[Note: these numbers reflect the data available in the June 14/16 (v6) data release. They may need to be updated prior to posting in the NIH Guide.]
- data from 372,000+ participants [, 80% from communities underrepresented in biomedical research overall (including racial and ethnic minorities, sexual and gender minorities, people living in rural areas, and other groups)].
- whole genome sequence data from nearly 100,000 participants (nearly 50% of whom self-identify as a member of a racial or ethnic minority group)
- 593,000,000+ unique variants, which Include 100M+ variants with = 3 occurrences not seen in gnomAD 3.0 (n = 71,702)
- electronic health record data from 258,000+ participants (including demographics, visits, diagnoses, COVID diagnoses and medications)
- survey data from 372,400 participants from nine different questionnaires capturing participant data on lifestyle, health care utilization and access, and COVID-19 participant experience.
- Fitbit data from more than 12,800+ participants who linked their personal data to their All of Us account
- physical measurements from 306,000+ participants (including blood pressure, heart rate, BMI, and more)
The All of Us dataset, available to scientists across the United States, provides unprecedented opportunities for a wide range of studies to understand how biological, behavioral, and environmental factors influence health and a broad range of diseases and conditions. The All of Us data are housed on the Researcher Workbench, which also includes tools, along with personalized support resources, such as an integrated help desk, regular office hours, sample datasets and more.
Research Objectives and Scope
Studies are encouraged that can help advance research in high priority mission areas of the NIH ICOs. The R03 award supports projects that use widely accepted approaches and methods.
Applications that develop new analytical tools and methods and apply them to investigations using the data in the All of Us Researcher Workbench should be directed to the companion R21 FOA (need to provide FOA number and link).
Applications must make direct use of All of Us data that are available through the Researcher Workbench. Applicants may analyze the All of Us data in combination with other existing datasets, but for the purpose of this administrative supplement program, they should not propose ancillary studies that would require the collection of additional data beyond what is already available in the Researcher Workbench or studies that would require a linkage of All of Us data to other datasets at the level of the individual.
Because information regarding the user experience could help NIH improve its data resources, it is expected that NIH will receive feedback from awardees on usability and utility of datasets and public data portals, which the awardees can provide in their progress reports to ICO Program Officers.
Applicants will be expected to make their workspace, and any tools they develop, available to other registered users of the All of Us Researcher Workbench.
Applicants may request funds, in addition to research costs, to present their work using All of Us data at a national meeting and/or All of Us Researchers Convention.
The combined budget for the two-year project period may not exceed $200,000 in direct costs. No more than $140,000 in direct costs may be requested in any single year.
March 01, 2023
Sheri Schully, Ph.D.; All of Us Research Program; Telephone: 240-827-1691; Email: schullys@mail.nih.gov