The Computational and Data-Enabled Science and Engineering in the Mathematical and Statistical Sciences (CDS&E-MSS) program in the Division of Mathematical Sciences (DMS) seeks to stimulate the creation and development of the next generation of mathematical and statistical computational tools and algorithms. These algorithms and tools should lead to innovation within mathematics and statistics while addressing the challenges presented by the ever-expanding role of computational experimentation, modeling, and simulation, and the explosion in production and analysis of digital data from experimental and observational sources. As part of this effort, this Dear Colleague Letter (DCL) invites proposals that aim to advance mathematics or statistics and address computational or data-oriented challenges with approaches that range from model-based to data-driven.