The DOE SC program in Basic Energy Sciences (BES) announces a re-competition of the Energy Frontier Research Center (EFRC) program and encourages both new and renewal applications. Applications from multi-disciplinary teams will be required to propose both discovery science and use-inspired basic research that addresses priority research directions and opportunities identified by a series of BES workshop and roundtable reports. DOE encourages applications that propose fundamental chemical sciences, materials sciences, geosciences, and biosciences research that will enable future clean energy technologies and advanced manufacturing. Coordination across programs is a high priority for DOE. EFRCs under this FOA will include awards for fundamental science that underpins the Energy Earthshots Initiative.