High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional)

PAR-22-069

The mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is to conduct and support medical research and research training and to disseminate science-based information on diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases, to improve people’s health and quality of life. To that end, the NIDDK, through extramural grants programs of its Programmatic Divisions, supports a broad range of biomedical research. 

            The purpose of the High Impact, Interdisciplinary Science grants program is to support high impact research that may lay the foundation for new fields of investigation within the mission of NIDDK.   The interdisciplinary approach encouraged by this FOA is envisioned to generate a research resource and/or foster discovery-based or hypothesis-generating science that can have a significant impact on the broader scientific community.   This FOA seeks novel approaches in areas that address specific knowledge gaps, scientific opportunities, new technologies, data generation, or research methods that will advance the area in significant ways designed to accelerate scientific progress in the understanding, treatment and prevention of diseases within the mission of the NIDDK.  
Scope and Specific Requirements

RC2 projects are intended to support :

• Groundbreaking, innovative, high impact and cross-cutting research projects that will improve and accelerate biomedical research.
• Basic, clinical, and translational projects that could fundamentally enhance the research enterprise and that require the participation, interaction, coordination and integration of activities carried out in multiple research laboratories.
• Creation of large-scale unique resources and/or development of transformative technologies that can benefit a wide range of investigators.
• High-impact discovery-based and hypothesis-generating science.

RC2 projects are not intended to support:

• Traditional investigator-initiated, hypothesis-driven and highly focused studies (best supported by the R01 or P01 mechanisms).
• Research that is a logical extension of ongoing work without a clear rationale for now requiring support through a RC2.
• Core (or related) services to supplement the budgets of existing R01-type efforts.
• Applications with a major emphasis outside of the mission of the NIDDK.

Prior Consultation with NIDDK

Consultation with NIDDK Scientific/Research staff listed in Section VII. Agency Contacts - Scientific/Research Contacts at least 3 months (and preferably 6 months) prior to the application due date (including resubmission applications) is strongly encouraged for submission of the High Impact, Interdisciplinary Science in NIDDK Research (RC2) application. NIDDK staff will consider whether the proposed RC2 meets the goals and mission of the Institute; whether it addresses one or more high priority research areas; and whether the application is best fit to the RC2 activity code, or whether the proposed work can be supported efficiently through traditional NIH funding mechanisms such as a large multi-PI R01.

The total annual cost for individual awards is expected to vary, depending on the scope of the project and the number of participating institutions. Application budgets are not limited but need to reflect the actual needs of the proposed project.

Six weeks prior to the application due date.

June 01, 2022, November 02, 2022

Norann Zaghloul, Ph.D., Division of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Telephone: 301-435-6677
Email: norann.zaghloul@nih.gov