High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional)

PAR-25-277

The mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is to conduct and support medical research and research training and to disseminate science-based information on diabetes and other endocrine and metabolic diseases; digestive diseases, hepatobiliary diseases, exocrine pancreatic disorders, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases, to improve health and quality of life for impacted communities and patient populations. To that end, the NIDDK, through extramural grants programs of its Programmatic Divisions, supports a broad range of biomedical research.

The purpose of the High Impact, Interdisciplinary Science grants program is to support high impact research that may lay the foundation for new fields of investigation within the mission of NIDDK. The interdisciplinary approach encouraged by this NOFO is envisioned to generate a research resource and/or foster discovery-based or hypothesis-generating science that can have a significant impact on the broader scientific community. This NOFO seeks novel approaches in areas that address specific knowledge gaps, scientific opportunities, new technologies, data generation, or research methods that will advance the area in significant ways designed to accelerate scientific progress in the understanding, treatment and prevention of diseases within the mission of the NIDDK.

Scope and Specific Requirements

RC2 projects are intended to support :

• Groundbreaking, innovative, high impact and cross-cutting research projects that will improve and accelerate biomedical research.
• Basic, clinical, and translational projects that could fundamentally enhance the research enterprise and that require the participation, interaction, coordination and integration of activities carried out in multiple research laboratories.
• Creation of large-scale unique resources and/or development of transformative technologies that can benefit a wide range of investigators.
• High-impact discovery-based and hypothesis-generating science.

RC2 projects are not intended to support:

• Traditional investigator-initiated, hypothesis-driven and highly focused studies (best supported by the R01 or mechanism).
• Research that is a logical extension of ongoing work without a clear rationale for now requiring support through a RC2.
• Core (or related) services to supplement the budgets of existing R01-type efforts.
• Applications with a major emphasis outside of the mission of the NIDDK.

The total annual cost for individual awards is expected to vary, depending on the scope of the project and the number of participating institutions. Application budgets are not limited but need to reflect the actual needs of the proposed project.

Four weeks prior to the application due date.

June 03, 2025; October 15, 2025

Norann Zaghloul, Ph.D.
Division of Diabetes, Endocrinology and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-435-6677
Email: norann.zaghloul@nih.gov

Patricia Greenwel, Ph.D.
Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-435-1169
Email: patricia.greenwel@nih.gov

Chris Mullins, Ph.D.
Division of Kidney, Urologic and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-451-4902
Email: mullinsc@extra.niddk.nih.gov