Publications
Publication
2024
61. Rady E. El-Araby, Qisheng Tu, Ying Xie, Tarek Aboushousha, Zhongyu Li,Xiaoyang Xu, Zoe X. Zhu, Lily Q. Dong, Jake Chen*, "Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes" ; Aging and Disease, 2024.
60. Bin Wang, Maoping Tang, Qijing Chen, William Ho, Yilong Teng, Xiaojian Xiong, Zhitong Jia, Xiuling Li, Xiaoyang Xu*, Xue-Qing Zhang* “Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion”; ACS. Nano, 2024.
59. Xin Bai, Qijing Chen, Fengqiao Li, Yilong Teng, Maoping Tang, Jia Huang, Xiaoyang Xu, Xue-Qing Zhang. "Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy". Nature Communication 15, 6844 (2024).
58. Mingzhu Gao, Yan Li, William Ho, Chen Chen, Qijing Chen, Fengshi Li, Maoping Tang, Qiuyue Fan, Jieqing Wan, Weifeng Yu, Xiaoyang Xu, Peiying Li, and Xue-Qing Zhang, "Targeted mRNA Nanoparticles Ameliorate Blood–Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization", ACS Nano, 2024
2023
57. Mingzhu Gao, Maoping Tang, William Ho, Yilong Teng, Qijing Chen, Lei Bu, Xiaoyang Xu, Xue-Qing Zhang, "Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis", ACS Nano, 2023
56. Fengqiao Li, Xue-Qing Zhang, William Ho, Maoping Tang, Zhongyu Li, Lei Bu, Xiaoyang Xu, "mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy", Nature Communications, 2023
55. Chenshuang Zhang, Yilong Teng, Fengqiao Li, William Ho, Xin Bai, Xiaoyang Xu, Xue-Qing Zhang, "Nanoparticle-Mediated RNA Therapy Attenuates Nonalcoholic Steatohepatitis and Related Fibrosis by Targeting Activated Hepatic Stellate Cells", ACS Nano, 2023
54. Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu, Xue-Qing Zhang, "Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer", ACS Appl. Mater. Interfaces, 2023
2022
53. Zhongyu Li, Xue-Qing Zhang, William Ho, Fengqiao Li, Mingzhu Gao, Xin Bai, Xiaoyang Xu, "Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines". ACS nano, 2022
52. Zhongyu Li, Xue-Qing Zhang, William Ho, Xin Bai, Dabbu Kumar Jaijyan, Fengqiao Li, Ranjeet Kumar, Afsal Kolloli, Selvakumar Subbian, Hua Zhu, Xiaoyang Xu, "Lipid-Polymer Hybrid “Particle-in-Particle” Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID-19 Vaccine". Advanced Functional Materials, 2022
51. Bai, Xin, Guolin Zhao, Qijing Chen, Zhongyu Li, Mingzhu Gao, William Ho, Xiaoyang Xu, and Xue-Qing Zhang. "Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge." Science Advances 8, no. 25 (2022): eabn7162. 
51.pdf
50. Wang, Bin, Maoping Tang, Ziwei Yuan, Zhongyu Li, Bin Hu, Xin Bai, Jinxian Chu, Xiaoyang Xu, and Xue-Qing Zhang. "Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy." Bioactive materials 16 (2022): 232-248. 50.pdf
49. Yuan, Ziwei, Bin Wang, Yilong Teng, William Ho, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu, and Xue-Qing Zhang. "Rational design of engineered H-ferritin nanoparticles with improved siRNA delivery efficacy across an in vitro model of the mouse BBB." Nanoscale 14, no. 17 (2022): 6449-6464. 49.pdf
2021
48. Injectable hydrogel mediated delivery of gene-engineered adipose-derived stem cells for enhanced osteoarthritis treatment Biomater. Sci., 2021,9, 7603-7616 48.pdf
47.Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis, Front Cell Dev Biol. 2021; 9: 703670. 47.pdf
46. Bin Hu, Mingzhu Gao, Kofi Oti Boakye-Yiadom, William Ho, Wei Yu, Xiaoyang Xu*, Xue-Qing Zhang* "An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing", Bioactive Materials 2021 46.pdf
45. William Ho, Mingzhu Gao, Fengqiao Li, Zhongyu Li, Xue‐Qing Zhang*, Xiaoyang Xu* "Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery", Advanced Healthcare Materials 2021 45.pdf
2020
44. Xue Tian, He Zhu, Shibin Du, Xue-Qing Zhang, Fuqing Lin, Fengtao Ji, Yung-Hao Tsou, Zhongyu Li, Yi Feng, Kathryn Ticehurst, Stephen Hannaford, Xiaoyang Xu, Yuan-Xiang Tao* “Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain”, the Journal of Pain 2020; 22,180-195. download44.pdf
43. Bin Hu, Kofi Oti Boakye-Yiadom, Wei Yu, Zi-wei Yuan, William Ho, Xiaoyang Xu*, Xue-Qing Zhang* “Nanomedicine Approaches for Advanced Diagnosis and Treatment of Atherosclerosis and Related Ischemic Diseases”. Adv. Healthcare Mater. 2020; (in press) download43.pdf
42. Qijing Chen, Mingzhu Gao, Zhongyu Li, Yue Xiaoa, Xin Bai, Kofi Oti Boakye-Yiadom, Xiaoyang Xu*, Xue-Qing Zhang* “Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy”, J. Control. Release 2020; 323, 179-190. download42.pdf
41. Zhongyu Li, William Ho, Xin Bai, Fengqiao Li, Yen-jui Chen, Xue-Qing Zhang, Xiaoyang Xu. "Nanoparticle depots for controlled and sustained gene delivery" Journal of Controlled Release. 2020. download41.pdf
2019
40. Zhize Yuan, Yung-Hao Tsou, Xueqing Zhang, Shixing Huang, Yang Yang, Mingzhu Gao, William Ho, Qiang Zhao, Xiaofeng Ye and Xiaoyang Xu. "Injectable Citrate-Based Hydrogel as an Angiogenic Biomaterial Improves Cardiac Repair after Myocardial Infarction" ACS Applied Materials & Interfaces. 2019. download40.pdf
39. Yung-Hao Tsou, Bin Wang, William Ho, Bin Hu, Pei Tang, Sydney Sweet, Xue-Qing Zhang,and Xiaoyang Xu. "Nanotechnology-Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities" Advanced Healthcare Materials. 2019. download39.pdf
2018
38. Zhanxian Li, Hanxiao Liu, Haixia Li, Yung-Hao Tsou, Yilin Gao, Xiaoyang Xu, Weiwei Dua, Liuhe Wei, Mingming Yu. "Lysosome-targeting NIR ratiometric luminecent upcoversion nanoprobe T toward arginine" Sensors and Actuators B: Chemical 280(2019) 94-101. download38.pdf
37. Chengde Wu, Xiaoyang Xu* “Exploring cutting-edge hydrogel technologies and their biomedical applications” Bioactive Materials 2018; 3(4), 446-447. download37.pdf
36. Yung-Hao Tsou, Xue-Qing Zhang, Yanlan Liu, He Zhu, Zhongyu Li, Jinjun Shi and Xiaoyang Xu. " Dopant-free hydrogels with intrinsic photoluminescent and biodegradable properties "Advanced Functional Materials. 2018. download36.pdf
35. Xin Bai, Mingzhu Gao, Sahla Syed, Jerry Zhuang, Xiaoyang Xu, Xue-Qing Zhang. " Bioactive Hydrogels for Bone Regeneration "Bioactive Materials. 2018 download35.pdf
34.Maocong Hu, Zhenhua Yao, Lili Li, Yung-Hao Tsou, Liyuan Kuang, Xiaoyang Xu, Wen Zhang and Xianqin Wang. " Boron-doped graphene nanosheets-supported Pt: highly active and selective catalyst for low temperature H2-SCR "Nanoscale.2018 download34.pdf
2017
33. Lei Wang, Xin Li, Tianyu Sun, Yung-Hao Tsou, Hong Chen, Xiaoyang Xu. “Dual-functional dextran-PEG hydrogel as an antimicrobial biomedical material” Macromol. Biosci. 2017. download32.pdf
32. Lei Wang, Benjamin Griffel, Xiaoyang Xu. “Synthesis of PLGA/lipid hybrid nanoparticles for siRNA delivery using emulsion method” Methods in Molecular Biology. 2017.
31. Yung-Hao Tsou, He Zhu, Sahla Syed, Xueqing Zhang and Xiaoyang Xu. "Drug delivery to the brain across the blood-brain barrier using nanomaterials". Small. 2017. download31.pdf
2016
30. William Ho, Xue-Qing Zhang, and Xiaoyang Xu. "Biomaterials in siRNA Delivery: A Comprehensive Review" Adv. Healthcare Mater. 2016. download30.pdf
29. Xun Gao, Yung-Hao Tsou, Marina Garisb, Haidong Huang, Xiaoyang Xu, Highly specific colorimetric detection of DNA oxidation biomarker using gold nanoparticle/triplex DNA conjugate. Nanomedicine: Nanotechnology, Biology and Medicine. 2016; (1 contribute equally) Download29.pdf
28. Yung-Hao Tsou, Joe Khoneisser, Ping-Chun Huang, Prof. Dr. Xiaoyang Xu. "Hydrogel as a bioactive material to regulate stem cell fate" Bioactive Materials. 2016; 1-17. Download28.pdf
27. Yuan Xue,1 Xiaoyang Xu, 1 Xueqing Zhang, Omid C Farokhzad, Robert S Langer. “Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles with drug delivery amplification” Proc Natl Acad Sci USA. 2016; (1 contribute equally) Download27.pdf
2015
26. Xi Zhu, Yingjie Xu, Luisa M Solis, Wei Tao, Liangzhe Wang, Carmen Behrens, Lili Zhao, Xiaoyang Xu, Danyl Liu, Jun Wu, Ning Zhang, Ignacio I Wistuba, Omid Farokhzad, Bruce R Zetter, Jinjun shi*. “Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment” Proc Natl Acad Sci USA. 2015; 112(25), 7779-84. Download26.pdf
25. Xiaoyang Xu*, William Ho, Xueqing Zhang, Nicolas Bertrand, and Omid Farokhzad*. “Cancer nanomedicine: from targeted delivery to combination therapy” Trends in molecular Medicine. 2015; 21, 233-244. Download25.pdf
24. Haisheng Peng, Chao Wang, Xiaoyang Xu, Chenxu Yu, and Qun Wang*. “An Intestinal Trojan Horse for Gene Delivery” Nanoscale 2015; 7, 4354-4360. Download24.pdf
23. Zhang, X.; Even-Or, O.; Xu, X.; Rosmalen, M.; Lim, L.; Gadde, S.; Farokhzad, O.; Fisher, E. A. “Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis” Adv. Healthcare Mater. 2015; 4(2):228-236. Download23.pdf
2014
22. Wu, J.; Kamly, N.; Shi, J.; Zhao, L.; Xiao, Z.; Hollett, G.; John, R.; Ray. S.; Xu, X.; Zhang, X; Kantoff, P.; Farokhzad C. O. “Development of multinuclear polymeric nanoparticles as robust protein nanocarriers” Angew. Chem. Int. Ed. 2014 Download.pdf
21. Shi, J.; Xu, Y.; Xu, X.; Zhu, X.; Pridgen, E.; Votruba, A.; Zetter, B.; Farokhzad C. O. “Hybrid Lipid-Polymer Nanoparticles for Sustained siRNA Delivery and Gene Silencing” Nanomed Nanotech Biol Med 2014 Download.pdf
20. Bertrand, N.; Wu, J.; Xu, X.; Kamaly, N.; Farokhzad, C. O. “Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology” Adv. Drug Deliv. Rev. 2014; 66, 2-25.Download.pdf
19. Xu, X; Xie, K; Zhang, X; Pridgen, E; Park, G; Lippard, S. J.; Langer, R. S.; Walker G. C.; Farokhzad C. O. “Enhancing Tumor Cell Response to Chemotherapy through Nanoparticle-Mediated Co-delivery of siRNA and Cisplatin Prodrug” Proc Natl Acad Sci USA. 2013; 110(46), 18638-18643.Download.pdf
18. Xu, X*; Zhang, X*; Bertrand, N; Pridgen, E; Swami A; Farokhzad C. O. “Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine” Adv. Drug Deliv. Rev.; 2012; 64(13), 1363-1384. (* equally contribute)Download.pdf
17. Cheng H; Byrska-Bishop M; Zhang T. C; Kastrup J. C; Hwang S. N; Tai K. A; Lee W. W; Xu X; Nahrendorf M; Langer S. R; Anderson G. D. “Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell–selectin interaction kinetics” Biomaterials; 2012; 33(20), 5004-5012.Download.pdf
16. Xu, X.; * Zhang, X.;* Lam, R.; Giljohann, D.; Ho, D.; and Mirkin C. A. “A Strategy for Increasing Drug Solubility and Efficacy through Covalent Attachment to Polycalent DNA-Nanoparticle Conjugates.” ACS Nano, 2011, 5 (9), 6962–6970. (* equally contribute) (9.855)Download.pdf
15. Zhang, X.; Lam, R.; Xu, X.; Kim, H.; and Ho. D. “Multimodal Nanodiamond Drug Delivery Carriers for Selective Targeting, Imaging and Enhanced Chemotherapeutic Efficacy” Adv. Mater. 2011; 23(41), 4770-4775.Download.pdf
14. Cutler, J. I.; Zheng, D.; Xu, X.; Jiyohann D. A.; Mirkin C. A. "Polyvalent Oligonucleotide Iron Oxide Nanoparticle "Click" Conjugates" Nano Lett.; 2010; 10 (4), 1477–1480.Download.pdf
13. Shimkunas, R; Robinson, E; Lam, R; Zhang, X; Xu, X; Ho, D. “Nanodiamond-Insulin Complexes as pH- Dependent Protein Delivery Vehicles.” Biomaterials. 2009; 30 (29), 5720-5728.Download.pdf
12. Xu, X.; Deniel, W.; Wei, W.; Mirkin, C. A. "Colorimetric Detection Cu2+ using DNA/Nanoparticle Conjugates and Click Chemistry " Small; 2009; 6 (5), 623-626 (7.333). Download12.pdf
11. Zhang, X; Chen, M; Lam, R; Xu, X; Ho, D; “Polymer-Functionalized Nanodiamond Platforms as Vehicles for Gene Delivery.” Acs Nano. 2009; 3(9), 2609-2616.Download.pdf
10. Xu, X.;* Song, Y.;* MacRenaris, K. W.; Zhang, X.; Mirkin, C. A.; Meade, T. J. " Multimodal Gadolinium-Enriched DNA Gold Nanoparticle Conjugates for Cellular Imaging" Angew. Chem. Int. Ed. 2009; 48(48), 9143-9147. (* equally contribute) (12.186)Download.pdf
9. Wei, W; Li, S; Millstone, J. E; Banholzer, M; Chen, X; Xu, X; Schatz, G. C.; Mirkin, C. A. "Surprisingly Long-Range Surface Enhanced Raman Scattering (SERS) on Au-Ni Multisegmented Nanowires" Angew. Chem. Int. Ed. 2009; 48, 4210-4212.Download.pdf
8. Zhang, X; Tang, H; Hosh, I; Laporte, L. D; Qiu, H; Xu, X; Shea, L. D.; Ameer, G. A."Sustained Transgene Expression via Citric Acid-based Polyester Elastomers" Biomaterials. 2009; 30(13), 2632- 2641.Download.pdf
7. Xu, X.; Zhao, Z.; Qin, L.; Wei, W.; Levin, J. E.; Mirkin, C. A. "A Fluorescence Recovery Assay for the Detection of Protein-DNA binding" Anal.Chem. 2008; 80(14); 5616-5621.(5.874)Download.pdf
6. Wei, W., Qin, L.; Xue, C.; Millstone, J. E.; Xu, X.; Li, S.; Schatz, G. C.; Mirkin, C. A."Surface Plasmon-Mediated Energy Transfer in Heterogap Au−Ag Nanowires" Nano Lett.; 2008; 8 (10), 3446–3449.Download.pdf
5. Millstone, J. E.; Georganopoulou, D. G.; Xu, X.; Payne. E. K.; Mirkin, C. A. "DNA-Gold Triangular Nanoprism Conjugates" Small; 2008; 4(12), 2176- 2180.Download.pdf
4. Xu, X.; Georganopoulou, D. G.; Hill, H. D.; Mirkin, C. A. "Homogeneous Detection of Nucleic Acids Based Upon the Light Scattering Properties of Silver-coated Nanoparticle Probes" Anal. Chem. 2007; 79(17); 6650-6654. (5.874)Download.pdf
3. Qin, L.; Banholzer, M. J.; Xu, X.; Huang, L.; Mirkin, C. A. "Rational Design and Synthesis of Catalytically Driven Nano Rotors " J. Am. Chem. Soc. 2007; 129(48); 14870-14871Download.pdf
2. Xu, X.; Han, M. S.; Mirkin, C. A. "A Gold-Nanoparticle-Based Real-Time Colorimetric Screening Method for Endonuclease Activity and Inhibition" Angew. Chem. Int. Ed. 2007; 46(19); 3468-3470. (Selected as "VIP paper") (12.186)Download.pdf
1. Xu, X.; Rosi, N. L.; Wang, Y.; Huo, F.; Mirkin, C. A. "Asymmetric Functionalization of Gold Nanoparticles with Oligonucleotides " J. Am. Chem. Soc. 2006; 128(29); 9286- 9287.( Highlighted by Nature Nanotechnology, 14 July 2006) (Impact factor: 9.019)Download.pdf
