NIMHD Exploratory/Developmental Research Grant Program (R21 - Clinical Trial Optional)

PAR-23-111

Projects are expected to focus on human and population-based studies in the biomedical, clinical, population, behavioral or social sciences. This can include research with human participants, in vitro studies that utilize human tissues to investigate mechanisms underlying resilience or susceptibility to disease, observational studies, epidemiologic studies, patient outcomes research, intervention research, dissemination and implementation research, and health services research. Animal studies will not be supported under this FOA.

Projects must include a focus on one or more NIH-designated health disparity populations in the US, which include Blacks or African Americans, Hispanics or Latinos, American Indians and Alaska Natives, Asians, Native Hawaiians and Other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities (SGM). Comparison groups may be included as appropriate for the research question(s) posed. Populations outside the US may be included if the purpose is to inform understanding of the health of immigrants in the US who belong to designated health disparity populations.

NIMHD has organized its extramural scientific programs around three broad research interest areas: 1) Clinical and Health Services Research, 2) Community Health and Population Sciences, and 3) Integrative Biological and Behavioral Sciences. The Clinical and Health Services Research area supports clinical research focused on improving patient health care outcomes and the quality of healthcare services for health disparity populations. The Community Health and Population Sciences area supports research on interpersonal, family, neighborhood, community and societal-level mechanisms and pathways that influence disease risk, resilience, morbidity, and mortality in health disparity populations. The Integrative Biological and Behavioral Sciences area supports research examining how human biological and behavioral mechanisms and pathways acting at the individual and interpersonal levels influence resilience and susceptibility to adverse health conditions that disproportionately affect health disparity populations. For details about these research areas please visit https://www.nimhd.nih.gov/programs/extramural/research-areas/.

Projects are expected to use multidisciplinary approaches encompassing multiple domains of influence (e.g., biological, behavioral, socio-cultural, environmental, physical environment, health system) and multiple levels of influence (e.g., individual, interpersonal, community, societal) to understand and address minority health and health disparities (see the NIMHD Research Framework, https://www.nimhd.nih.gov/about/overview/research-framework.html, for more information).

The combined budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.

Not required

June 16, 2023; October 16, 2023

Please use the links below to identify Scientific/Research Contacts:

Community Health and Population Sciences
Clinical and Health Services Research
Integrative Biological and Behavioral Sciences