The solicitation calls for proposals focused on understanding the mechanistic underpinnings of organismal response to climate change to improve our ability to predict and to mitigate maladaptive biological responses to rapidly changing environments and to facilitate organismal adaptation and persistence. In particular, proposals are sought that integrate the study of genomic, physiological, structural, developmental, neural, or behavioral mechanisms of organismal response to climate change (ORCC) with eco-evolutionary approaches to better manage the effects of a rapidly changing climate on earth’s living systems. Specific areas of emphasis include but are not limited to: integrating physiology and genomics into the next generation of species distribution models; mechanistic understanding of plastic responses to climate change; functional genomics of organismal response to climate change; the role biological interactions play in organismal responses to climate change; and improving our ability to predict how organisms will respond to climate change and the consequences these responses will have across biological scales.