The Quantum Sensing Challenges for Transformational Advances in Quantum Systems (QuSeC-TAQS) program supports interdisciplinary teams of three (3) or more investigators to explore highly innovative, original, and potentially transformative research on quantum sensing. The QuSeC-TAQS program supports coordinated efforts to develop and apply quantum sensor systems, with demonstrations resulting in proof of principle or field-testing of concepts and platforms that can benefit society. The QuSeC-TAQS program aligns with recommendations articulated in the strategy report, Bringing Quantum Sensors to Fruition, that was produced by the National Science and Technology Council Subcommittee on Quantum Information Science, under the auspices of the National Quantum Initiative.