This Notice of Funding Opportunity (NOFO) invites eligible shared biomedical research facilities to buy new small instruments or scientific equipment. These facilities may include core facilities, biorepositories, model resource facilities, and other research spaces or resources that are shared by multiple researchers. The goal is to help these facilities improve, update, and operate more efficiently. Organizations are especially encouraged to request funding for small instruments that use new or emerging technologies or that produce physical, chemical, or biomaterial outputs other than conventional digital data. This funding cannot be used to buy highly specialized research instruments or building-level infrastructure equipment that only indirectly supports research.