NIH Research Program Projects (Parent P01 Clinical Trial Optional)

Specific Research Objectives

Through this NOFO, NIH invites applications proposing multidisciplinary, coordinated research programs that represent the investigators' specific interests and competencies and that fall within the mission of the participating NIH Institutes Centers, and Offices (ICOs). The goal of the Program Project is to support an integrated, collaborative research program composed of interrelated projects that address a well-defined central research focus or objective. Individual research projects should be scientifically meritorious and contribute synergistically to the overall Program, providing added value through scientific integration and collaboration. Refer to NIH Institute, Center, and Office Grants & Funding Profiles for ICO-specific missions, interest areas, priorities, and funding considerations.

Synergy in Multi-project Applications

This NOFO supports multi-project applications. In the context of a multi-project application, synergy entails cooperative interaction of multiple projects, teams, or resources to produce a combined effect greater than the sum of their separate parts for enhancement of scientific knowledge, ideas, and outcomes. The proposed merger of complementary skills, perspectives, and resources has the potential to produce outcomes greater than would otherwise be achieved. The outcomes resulting from conducting the proposed research as a Program will exceed the outcomes from conducting separate research activities as a single project application. Resources and tools that can help facilitate synergy include, but are not limited to sharing research data, samples, reagents, pathogens, human subject cohort(s), technologies, research approaches, data management/analytical tools, and model organisms.