The Computational Biofluid Dynamics Lab focuses on the simulation of bio-inspired fluid dynamics using high performance computing. We use an in-house, state-of-the-art method which couples fluid mechanics and solid mechanics models in 3D to enable new scientific discoveries. Our high-resolution simulations can capture biological cells, such as red blood cells or cancer cells, deforming and flowing in dense suspensions through complex 3D networks of blood vessels. Our recent projects include new method development and modeling in the area of angiogenesis, the growth of new blood vessels. Through collaboration with experiment-based researchers we are developing new technology to enable predictions of microvascular growth in 3D. Potential impacts include helping to predict tumor growth patterns and informing new treatment approaches; improving blood flow in heart disease through re-vascularization; and aiding in the healing process following injury. We are also working to build a new understanding of cancer cell transport through complex blood vessels, as well as blood rheology and the influences of disease and aging.