R3PEATS Multi-Team Triangulation supports coordinated teams to investigate a central biomedical research question through complementary methods, model systems, or populations. Projects must identify signal robustness and sources of biological variability while building replication into the research design. This effort is a part of the NIH Common Fund's Rigor, Replicability, & Reproducibility to Promote Excellence, Accuracy, & Translation in Science (R3PEATS) program.