The Keck Laboratory for Topological Materials uses interdisciplinary research to investigate the existence of what are known as topological phonons in microtubules (MTs), a naturally occurring biological material. Our theoretical evidence suggests that topological phonons are integral to the function of MTs – a cytoskeletal component in all eukaryotic cells that is essential for many fundamental cellular processes, including cell division and movement. Inspired by the mechanical properties of the microtubules, we work on laying the theoretical and experimental foundation for a new class of engineered materials that exhibit the unique vibrational and thermal properties of topological phonon edgemodes. Such materials may find application in sound deadening and amplification, and the management of heat flow.